The Inter-ministerial National Structural Intervention Trial (INSTRUCT) is a partnership between the Government of Botswana and CIET, an academic non-governmental organization.

INSTRUCT is led by the National AIDS Coordinating Agency (NACA) and CIET, and supported by the Ministry of Health and the Ministry of Local Government.

The INSTRUCT Working Group, with members from NACA, CIET, MoH and MOLG, reports to the HIV Prevention Think Tank, a high-level strategic advisory group.